Ultimately, I agree with Miller et al. that the moral principles which govern clinical medical practice should not be confused with the moral principles which should govern clinical medical research. While the Principles of Non-Maleficence , Clinical Equipoise , and Beneficence  ought to be strictly observed within the context of clinical practice, the differences in purposes, methodology, and costs of clinical practice compared to clinical research make it clear that they are not the same and should not be treated as such. But I am also sympathetic, at least in part, to Freedman et al. in that there is still room for significant improvement. As a result, I seek to argue for a kind of middle ground in this particular debate.